The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

Dongmei Bai; Jinfang Zhang; Tingting Li; Runlai Hang; Yong Liu; Yonglu Tian; Dadu Huang; Linglong Qu; Xiaofeng Cao; Jiafu Ji; Xiaofeng Zheng

doi:10.1038/ncomms12310

Nature Communications (Aug 2016)

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

Dongmei Bai,
Jinfang Zhang,
Tingting Li,
Runlai Hang,
Yong Liu,
Yonglu Tian,
Dadu Huang,
Linglong Qu,
Xiaofeng Cao,
Jiafu Ji,
Xiaofeng Zheng

Affiliations

Dongmei Bai: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Jinfang Zhang: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Tingting Li: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Runlai Hang: State key Laboratory of Plant Genetics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Yong Liu: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Yonglu Tian: Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University
Dadu Huang: Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University
Linglong Qu: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University
Xiaofeng Cao: State key Laboratory of Plant Genetics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Jiafu Ji: Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Caner Hospital and Institute
Xiaofeng Zheng: State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/ncomms12310
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

Read online

Perturbations in ribosome biogenesis affect development and increase cancer susceptibility. Here, the authors show that hCINAP is required for 18S rRNA processing, is highly expressed in cancers, and promotes cancer cell growth by upregulating the translation of cancer-associated genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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