Frontiers in Medicine (Dec 2020)
COVID-19 Induced Acute Respiratory Distress Syndrome—A Multicenter Observational Study
- Johannes Herrmann,
- Elisabeth Hannah Adam,
- Quirin Notz,
- Philipp Helmer,
- Michael Sonntagbauer,
- Peter Ungemach-Papenberg,
- Andreas Sanns,
- York Zausig,
- Thorsten Steinfeldt,
- Iuliu Torje,
- Benedikt Schmid,
- Tobias Schlesinger,
- Caroline Rolfes,
- Christian Reyher,
- Markus Kredel,
- Jan Stumpner,
- Alexander Brack,
- Thomas Wurmb,
- Daniel Gill-Schuster,
- Peter Kranke,
- Dirk Weismann,
- Hartwig Klinker,
- Peter Heuschmann,
- Peter Heuschmann,
- Viktoria Rücker,
- Stefan Frantz,
- Georg Ertl,
- Ralf Michael Muellenbach,
- Haitham Mutlak,
- Patrick Meybohm,
- Kai Zacharowski,
- Christopher Lotz
Affiliations
- Johannes Herrmann
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Elisabeth Hannah Adam
- Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany
- Quirin Notz
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Philipp Helmer
- Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany
- Michael Sonntagbauer
- Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany
- Peter Ungemach-Papenberg
- Department of Anesthesiology and Critical Care, Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany
- Andreas Sanns
- Department of Anesthesiology and Critical Care, Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany
- York Zausig
- Department of Anesthesiology and Critical Care, Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Germany
- Thorsten Steinfeldt
- Department of Anesthesiology and Critical Care, Diakoneo Diak Klinikum Schwabisch Hall, Schwabisch-Hall, Germany
- Iuliu Torje
- Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton, Southampton, Germany
- Benedikt Schmid
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Tobias Schlesinger
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Caroline Rolfes
- Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton, Southampton, Germany
- Christian Reyher
- Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton, Southampton, Germany
- Markus Kredel
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Jan Stumpner
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Alexander Brack
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Thomas Wurmb
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Daniel Gill-Schuster
- Department of Anesthesiology and Critical Care, Sana-Klinikum Offenbach GmbH, Offenbach, Germany
- Peter Kranke
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Dirk Weismann
- Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
- Hartwig Klinker
- Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany
- Peter Heuschmann
- Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-University, Würzburg, Germany
- Peter Heuschmann
- 0Clinical Trial Center, University Hospital Würzburg, Julius-Maximilians-University, Würzburg, Germany
- Viktoria Rücker
- Institute for Clinical Epidemiology and Biometry, Julius-Maximilians-University, Würzburg, Germany
- Stefan Frantz
- Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
- Georg Ertl
- Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany
- Ralf Michael Muellenbach
- Department of Critical Care, Emergency Medicine and Anesthesiology, ARDS/ECMO-Centre, Campus Kassel of the University of Southampton, Southampton, Germany
- Haitham Mutlak
- Department of Anesthesiology and Critical Care, Sana-Klinikum Offenbach GmbH, Offenbach, Germany
- Patrick Meybohm
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- Kai Zacharowski
- Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany
- Christopher Lotz
- Department of Anesthesiology and Critical Care, University Hospital Würzburg, Julius-Maximilians-University Würzburg, Würzburg, Germany
- DOI
- https://doi.org/10.3389/fmed.2020.599533
- Journal volume & issue
-
Vol. 7
Abstract
Background: Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS).Methods: This is a retrospective, observational multicentre study in five German secondary or tertiary care hospitals. All patients consecutively admitted to the intensive care unit (ICU) in any of the participating hospitals between March 12 and May 4, 2020 with a COVID-19 induced ARDS were included.Results: A total of 106 ICU patients were treated for COVID-19 induced ARDS, whereas severe ARDS was present in the majority of cases. Survival of ICU treatment was 65.0%. Median duration of ICU treatment was 11 days; median duration of mechanical ventilation was 9 days. The majority of ICU treated patients (75.5%) did not receive any antiviral or anti-inflammatory therapies. Venovenous (vv) ECMO was utilized in 16.3%. ICU triage with population-level decision making was not necessary at any time. Univariate analysis associated older age, diabetes mellitus or a higher SOFA score on admission with non-survival during ICU stay.Conclusions: A high level of care adhering to standard ARDS treatments lead to a good outcome in critically ill COVID-19 patients.
Keywords
