Technology in Cancer Research & Treatment (Mar 2022)

Assessing Bone Marrow Activity with []FLT PET in Patients with Essential Thrombocythemia and Prefibrotic Myelofibrosis: A Proof of Concept

  • Mohamed A. Yassin MBBS, CABM, MSC, FACP, MSC,
  • Sadek A. Nehmeh PhD,
  • Abdulqadir J. Nashwan MSc,
  • Samah A. Kohla PhD,
  • Shehab F. Mohamed MD,
  • Omar M. Ismail MD,
  • Ahmad Al Sabbagh PhD,
  • Dina S. Soliman PhD,
  • Lajos Szabados MD,
  • Hadi Fayad PhD

DOI
https://doi.org/10.1177/15330338221086396
Journal volume & issue
Vol. 21

Abstract

Read online

Objectives: This study aims to assess the value of FLT-PET as a non-invasive tool to differentiate between patients with ET and Pre-PMF. This study is a pilot study to have a proof of concept only. Methods: This is a prospective, interventional study where a total of 12 patients were included. Each patient underwent FLT PET imaging as well as bone marrow examination (gold standard). In addition, semi-quantitative (SUVmax and SUVmean) measurements of FLT uptake in the liver, spleen, and Lspine, SUVmean, as well as the Total Lesion Glycolysis (TLG) of the Lspine were performed. Results from the two patient cohorts were compared using = Kruskal-Wallis statistical test. A P -value of .05). In contrast, TLG measurements in the LSpine were statistically different ( P = .013), and therefore, compared to gold standard bone marrow results, TLG can separate ET and Pre-PMF patients. Conclusion: This study is a proof of concept about the potential to discriminate between ET and pre-PMF patients in a non-invasive way. TLG of the LSpine in FLT PET images is a potential quantitative parameter to distinguish between ET and pre-PMF patients.