Emerging Microbes and Infections (Dec 2023)

Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination

  • Markus H. Kainulainen,
  • Jessica R. Harmon,
  • Amy N. Whitesell,
  • Éric Bergeron,
  • Elif Karaaslan,
  • Caitlin M. Cossaboom,
  • Jason H. Malenfant,
  • Aaron Kofman,
  • Joel M. Montgomery,
  • Mary J. Choi,
  • César G. Albariño,
  • Christina F. Spiropoulou

DOI
https://doi.org/10.1080/22221751.2023.2265660
Journal volume & issue
Vol. 12, no. 2

Abstract

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Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine.

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