Communications Biology (Jul 2022)
Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression
- Jamie Zagozewski,
- Stephanie Borlase,
- Brent J. Guppy,
- Ludivine Coudière-Morrison,
- Ghazaleh M. Shahriary,
- Victor Gordon,
- Lisa Liang,
- Stephen Cheng,
- Christopher J. Porter,
- Rhonda Kelley,
- Cynthia Hawkins,
- Jennifer A. Chan,
- Yan Liang,
- Jingjing Gong,
- Carolina Nör,
- Olivier Saulnier,
- Robert J. Wechsler-Reya,
- Vijay Ramaswamy,
- Tamra E. Werbowetski-Ogilvie
Affiliations
- Jamie Zagozewski
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Stephanie Borlase
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Brent J. Guppy
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Ludivine Coudière-Morrison
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Ghazaleh M. Shahriary
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Victor Gordon
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Lisa Liang
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Stephen Cheng
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- Christopher J. Porter
- Ottawa Bioinformatics Core Facility, Ottawa Hospital Research Institute
- Rhonda Kelley
- Central Animal Care Services, University of Manitoba
- Cynthia Hawkins
- The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Jennifer A. Chan
- Department of Pathology & Laboratory Medicine, University of Calgary
- Yan Liang
- Pathology Department, NanoString Inc
- Jingjing Gong
- Pathology Department, NanoString Inc
- Carolina Nör
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Olivier Saulnier
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Robert J. Wechsler-Reya
- Sanford Burnham Prebys Medical Discovery Institute
- Vijay Ramaswamy
- The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Tamra E. Werbowetski-Ogilvie
- Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba
- DOI
- https://doi.org/10.1038/s42003-022-03654-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
RNA sequencing of MEK inhibitor (selumetinib)-treated tumors reveals an upregulation of the JAK/STAT3 pathway, with combinatorial therapeutic strategies of JAK/STAT3 inhibitors and selumetinib investigated for the SHH subgroup of medulloblastoma.
