IL-6和动脉粥样硬化性缺血性卒中的关系研究进展 Advances in the Relationship between IL-6 and Atherosclerotic Ischemic Stroke

Abstract

缺血性卒中是一种病因复杂的综合征，其中动脉粥样硬化是主要病因之一。流行病学、分子生物学证据表明IL-6促进动脉粥样硬化斑块的形成和生长，影响缺血性卒中的发生、发展及预后。新近的临床研究进一步证实干预IL-6通路有望成为缺血性卒中治疗的新靶点。本综述从分子生物学、流行病学和新近开展的临床研究阐述IL-6在缺血性卒中发生、预后中的作用，以及作为潜在治疗靶点的可能性。 Abstract: Ischemic stroke is a complex syndrome, and atherosclerosis is one of the main causes. Interleukin 6 (IL-6) is an important inflammatory factor involved in atherosclerosis. The epidemiological and molecular biological evidence indicated that IL-6 can promote the formation and growth of atherosclerosis plaque and influence the occurrence, development and prognosis of ischemic stroke. Recent clinical studies further suggested IL-6 may be a potential therapeutic target of ischemic stroke. This review aimed to elaborate the role of IL-6 in the occurrence and prognosis of ischemic stroke from the perspectives of molecular mechanism, epidemiology and clinical research.

Keywords

• 缺血性卒中
• 动脉粥样硬化
• 白介素-6
• 炎症
• 心血管疾病
• ischemic stroke
• atherosclerosis
• interleukin 6
• inflammation
• cardiovascular disease