Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Joonbeom Bae; Sang-Pil Choi; Kyoichi Isono; Ji Yoon Lee; Si-Won Park; Chang-Yong Choi; Jihye Han; Sang-Hoon Kim; Han-Hyoung Lee; Kyungmin Park; Hyun Yong Jin; Suk Jun Lee; Chung-Gyu Park; Haruhiko Koseki; Young Sik Lee; Taehoon Chun

doi:10.1038/s41467-019-11386-4

Nature Communications (Aug 2019)

Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

Joonbeom Bae,
Sang-Pil Choi,
Kyoichi Isono,
Ji Yoon Lee,
Si-Won Park,
Chang-Yong Choi,
Jihye Han,
Sang-Hoon Kim,
Han-Hyoung Lee,
Kyungmin Park,
Hyun Yong Jin,
Suk Jun Lee,
Chung-Gyu Park,
Haruhiko Koseki,
Young Sik Lee,
Taehoon Chun

Affiliations

Joonbeom Bae: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Sang-Pil Choi: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Kyoichi Isono: Laboratory Animal Center, Wakayama Medical University
Ji Yoon Lee: Department of Biomedical Science, CHA University
Si-Won Park: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Chang-Yong Choi: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Jihye Han: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Sang-Hoon Kim: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Han-Hyoung Lee: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Kyungmin Park: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Hyun Yong Jin: Department of Urology, School of Medicine, University of California, San Francisco
Suk Jun Lee: Department of Biomedical Laboratory Science, College of Health Science, Cheongju University
Chung-Gyu Park: Department of Microbiology and Immunology, Cancer Research Institute and Xenotransplantation Research Center, Seoul National University College of Medicine
Haruhiko Koseki: Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences
Young Sik Lee: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University
Taehoon Chun: Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University

DOI: https://doi.org/10.1038/s41467-019-11386-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Mobilization of hematopoietic stem and progenitor cells (HSPCs) into the circulation is essential for maintaining homeostasis. Here, the authors show that Phc2 in bone marrow stromal cells represses the cell adhesion molecule Vcam1 and facilitates mobilization of HSPCs through regulation of epigenetic marks.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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