Pyrosequencing Assay to Rapidly Detect Clarithromycin Resistance Mutations in Canadian Helicobacter pylori Isolates

R Slinger; L Yan; F Chan; K Forward; G Cooper-Lesins; L Best; D Haldane; S Veldhuyzen van Zanten

doi:10.1155/2009/695349

Canadian Journal of Gastroenterology (Jan 2009)

Pyrosequencing Assay to Rapidly Detect Clarithromycin Resistance Mutations in Canadian Helicobacter pylori Isolates

R Slinger,
L Yan,
F Chan,
K Forward,
G Cooper-Lesins,
L Best,
D Haldane,
S Veldhuyzen van Zanten

Affiliations

R Slinger: Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
L Yan: EpigenDx Inc, Worcester, Massachusetts, USA
F Chan: Children’s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada
K Forward: Dalhousie University, Halifax, Nova Scotia, Canada
G Cooper-Lesins: Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
L Best: Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
D Haldane: Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
S Veldhuyzen van Zanten: University of Alberta, Edmonton, Alberta, Canada

DOI: https://doi.org/10.1155/2009/695349
Journal volume & issue: Vol. 23, no. 9
pp. 609 – 612

Abstract

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BACKGROUND: Mutations at positions 2142 or 2143 in the two-copy 23S ribosomal RNA gene of Helicobacter pylori are highly predictive of in vitro clarithromycin resistance and failure of clarithromycin-containing treatment regimens.

Published in Canadian Journal of Gastroenterology

ISSN: 0835-7900 (Print); 1916-7237 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.hindawi.com/journals/cjgh/

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