A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe<sup>3+</sup>

Axel Steinbrueck; Adam C. Sedgwick; Suh-Mi Hwang; Sajal Sen; Michael Y. Zhao; Dan-Ying Huang; Daniel M. Knoll; Yu-Ying Wang; Jonathan L. Sessler

doi:10.3390/chemosensors9040068

Chemosensors (Mar 2021)

A Deferasirox Derivative That Acts as a Multifaceted Platform for the Detection and Quantification of Fe<sup>3+</sup>

Axel Steinbrueck,
Adam C. Sedgwick,
Suh-Mi Hwang,
Sajal Sen,
Michael Y. Zhao,
Dan-Ying Huang,
Daniel M. Knoll,
Yu-Ying Wang,
Jonathan L. Sessler

Affiliations

Axel Steinbrueck: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Adam C. Sedgwick: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Suh-Mi Hwang: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Sajal Sen: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Michael Y. Zhao: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Dan-Ying Huang: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Daniel M. Knoll: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Yu-Ying Wang: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA
Jonathan L. Sessler: Department of Chemistry, The University of Texas at Austin, 105 E 24th Street A5300, Austin, TX 78712-1224, USA

DOI: https://doi.org/10.3390/chemosensors9040068
Journal volume & issue: Vol. 9, no. 4
p. 68

Abstract

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Here, we report that ExSO3H, a synthetically accessible, water-soluble, non-toxic derivative of the clinical iron chelator deferasirox, acts as a colorimetric chemosensor that permits the detection and quantification of Fe3+ in aqueous samples at pH 2–5. In addition, we observed that a fluorescent turn-on response was produced when this chelator was allowed to interact with human serum albumin (HSA). This fluorescence was quenched in the presence of Fe3+, thus allowing us to monitor the presence of this biologically important metal cation via two independent methods.

Published in Chemosensors

ISSN: 2227-9040 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: http://www.mdpi.com/journal/chemosensors

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