Structure of the full-length TRPV2 channel by cryo-EM

Kevin W. Huynh; Matthew R. Cohen; Jiansen Jiang; Amrita Samanta; David T. Lodowski; Z. Hong Zhou; Vera Y. Moiseenkova-Bell

doi:10.1038/ncomms11130

Nature Communications (Mar 2016)

Structure of the full-length TRPV2 channel by cryo-EM

Kevin W. Huynh,
Matthew R. Cohen,
Jiansen Jiang,
Amrita Samanta,
David T. Lodowski,
Z. Hong Zhou,
Vera Y. Moiseenkova-Bell

Affiliations

Kevin W. Huynh: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Wood Building, W151D, Cleveland, Ohio 44106, USA
Matthew R. Cohen: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Wood Building, W151D, Cleveland, Ohio 44106, USA
Jiansen Jiang: Department of Microbiology, Immunology and Molecular Genetics, University of California
Amrita Samanta: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Wood Building, W151D, Cleveland, Ohio 44106, USA
David T. Lodowski: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Wood Building, W151D, Cleveland, Ohio 44106, USA
Z. Hong Zhou: Department of Microbiology, Immunology and Molecular Genetics, University of California
Vera Y. Moiseenkova-Bell: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Wood Building, W151D, Cleveland, Ohio 44106, USA

DOI: https://doi.org/10.1038/ncomms11130
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 8

Abstract

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Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation of the TRPV subfamily of channels.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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