The Circular RNA Profiles of Colorectal Tumor Metastatic Cells

Weiqin Jiang; Xingchen Zhang; Xingchen Zhang; Qinjie Chu; Sen Lu; Linfu Zhou; Xingang Lu; Xingang Lu; Chen Liu; Lingfeng Mao; Chuyu Ye; Michael P. Timko; Longjiang Fan; Longjiang Fan; Haixing Ju

doi:10.3389/fgene.2018.00034

Frontiers in Genetics (Feb 2018)

The Circular RNA Profiles of Colorectal Tumor Metastatic Cells

Weiqin Jiang,
Xingchen Zhang,
Xingchen Zhang,
Qinjie Chu,
Sen Lu,
Linfu Zhou,
Xingang Lu,
Xingang Lu,
Chen Liu,
Lingfeng Mao,
Chuyu Ye,
Michael P. Timko,
Longjiang Fan,
Longjiang Fan,
Haixing Ju

Affiliations

Weiqin Jiang: Cancer Biotherapy Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Xingchen Zhang: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Xingchen Zhang: Research Center for Air Pollution and Health, Hangzhou, China
Qinjie Chu: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Sen Lu: Departments of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China
Linfu Zhou: Medical Biotechnology Laboratory, Zhejiang University, Hangzhou, China
Xingang Lu: The 2nd Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, China
Xingang Lu: Zhejiang Cancer Hospital, Hangzhou, China
Chen Liu: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Lingfeng Mao: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Chuyu Ye: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Michael P. Timko: Departments of Biology and Public Health Science, University of Virginia, Charlottesville, VA, United States
Longjiang Fan: Department of Agronomy, Institute of Bioinformatics, Zhejiang University, Hangzhou, China
Longjiang Fan: Research Center for Air Pollution and Health, Hangzhou, China
Haixing Ju: Zhejiang Cancer Hospital, Hangzhou, China

DOI: https://doi.org/10.3389/fgene.2018.00034
Journal volume & issue: Vol. 9

Abstract

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Circular RNAs (circRNAs) have been reported that can be used as biomarkers for colorectal cancers (CRC) and other types of tumors. However, a limited number of studies have been performed investigating the potential role of circRNAs in tumor metastasis. Here, we examined the circRNAs in two CRC cell lines (a primary tumor cell SW480 and its metastasis cell SW620), and found a large set of circRNA (2,919 ncDECs) with significantly differential expression patterns relative to normal cells (NCM460). In addition, we uncovered a set of 623 pmDECs that differ between the primary CRC cells and its metastasis cells. Both differentially expressed circRNA (DEC) sets contain many previously unknown putative CRC-related circRNAs, thereby providing many new circRNAs as candidate biomarkers for CRC development and metastasis. These studies are the first large-scale identification of metastasis-related circRNAs for CRC and provide valuable candidate biomarkers for diagnostic and a starting point for additional investigations of CRC metastasis.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

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