Nature Communications (Nov 2019)
Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
- Nicola P. Montaldo,
- Diana L. Bordin,
- Alessandro Brambilla,
- Marcel Rösinger,
- Sarah L. Fordyce Martin,
- Karine Øian Bjørås,
- Stefano Bradamante,
- Per Arne Aas,
- Antonia Furrer,
- Lene C. Olsen,
- Nicolas Kunath,
- Marit Otterlei,
- Pål Sætrom,
- Magnar Bjørås,
- Leona D. Samson,
- Barbara van Loon
Affiliations
- Nicola P. Montaldo
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Diana L. Bordin
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Alessandro Brambilla
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Marcel Rösinger
- Department of Molecular Mechanisms of Disease, University of Zurich
- Sarah L. Fordyce Martin
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Karine Øian Bjørås
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Stefano Bradamante
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Per Arne Aas
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Antonia Furrer
- Department of Molecular Mechanisms of Disease, University of Zurich
- Lene C. Olsen
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Nicolas Kunath
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Marit Otterlei
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Pål Sætrom
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Magnar Bjørås
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- Leona D. Samson
- Department of Biological Engineering, Department of Biology, David H. Koch Institute of integrative Cancer Research, Massachusetts Institute of Technology
- Barbara van Loon
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)
- DOI
- https://doi.org/10.1038/s41467-019-13394-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
How genome stability is maintained at regions of active transcription is currently not entirely clear. Here, the authors reveal an association between base excision repair factors and transcription elongation to modulate DNA repair.
