Nature Communications (Mar 2021)
Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae
- Robert C. Will,
- Thandavarayan Ramamurthy,
- Naresh Chand Sharma,
- Balaji Veeraraghavan,
- Lucky Sangal,
- Pradeep Haldar,
- Agila Kumari Pragasam,
- Karthick Vasudevan,
- Dhirendra Kumar,
- Bhabatosh Das,
- Eva Heinz,
- Vyacheslav Melnikov,
- Stephen Baker,
- Vartul Sangal,
- Gordon Dougan,
- Ankur Mutreja
Affiliations
- Robert C. Will
- Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge
- Thandavarayan Ramamurthy
- Translational Health Science and Technology Institute
- Naresh Chand Sharma
- Maharishi Valmiki Infectious Diseases Hospital
- Balaji Veeraraghavan
- Department of Clinical Microbiology, Christian Medical College
- Lucky Sangal
- World Health Organization
- Pradeep Haldar
- Ministry of Health and Family Welfare, Govt. of India
- Agila Kumari Pragasam
- Department of Clinical Microbiology, Christian Medical College
- Karthick Vasudevan
- Department of Clinical Microbiology, Christian Medical College
- Dhirendra Kumar
- Translational Health Science and Technology Institute
- Bhabatosh Das
- Translational Health Science and Technology Institute
- Eva Heinz
- Department of Vector Biology, Liverpool School of Tropical Medicine
- Vyacheslav Melnikov
- Gabrichevsky Research Institute for Epidemiology and Microbiology
- Stephen Baker
- Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge
- Vartul Sangal
- Faculty of Health and Life Sciences, Northumbria University
- Gordon Dougan
- Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge
- Ankur Mutreja
- Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge
- DOI
- https://doi.org/10.1038/s41467-021-21870-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Cases of diphtheria have increased in recent years. Here, the authors analyse the genomes of 502 Corynebacterium diphtheriae isolates across 16 countries and territories over 122 years, describing an increase in antimicrobial resistance genes and identifying toxin variants.
