Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

Chenxu Yan; Zhiqian Guo; Weijie Chi; Wei Fu; Syed Ali Abbas Abedi; Xiaogang Liu; He Tian; Wei-Hong Zhu

doi:10.1038/s41467-021-24187-5

Nature Communications (Jun 2021)

Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

Chenxu Yan,
Zhiqian Guo,
Weijie Chi,
Wei Fu,
Syed Ali Abbas Abedi,
Xiaogang Liu,
He Tian,
Wei-Hong Zhu

Affiliations

Chenxu Yan: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Zhiqian Guo: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Weijie Chi: Fluorescence Research Group, Singapore University of Technology and Design
Wei Fu: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Syed Ali Abbas Abedi: Fluorescence Research Group, Singapore University of Technology and Design
Xiaogang Liu: Fluorescence Research Group, Singapore University of Technology and Design
He Tian: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology
Wei-Hong Zhu: Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Shanghai Key Laboratory of Functional Materials Chemistry, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science & Technology

DOI: https://doi.org/10.1038/s41467-021-24187-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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The electron-withdrawing target (EWT)-induced fluorescence quenching is an unsolved issue in intramolecular charge transfer (ICT) fluorophores that limits their applicability. Here, the authors report a simple and generalizable strategy to reverse the EWT-induced quenching mode into light-up mode, by introducing an indazole building block between the π-bridge and the donor in the ICT scaffold.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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