Deciphering the role of miRNA-134 in the pathophysiology of depression: A comprehensive review

Yunkai Wang; Yali Huang; Xuexing Luo; Xin Lai; Lili Yu; Ziming Zhao; Aijia Zhang; Hong Li; Guanghui Huang; Yu Li; Jue Wang; Qibiao Wu

Heliyon (Oct 2024)

Deciphering the role of miRNA-134 in the pathophysiology of depression: A comprehensive review

Yunkai Wang,
Yali Huang,
Xuexing Luo,
Xin Lai,
Lili Yu,
Ziming Zhao,
Aijia Zhang,
Hong Li,
Guanghui Huang,
Yu Li,
Jue Wang,
Qibiao Wu

Affiliations

Yunkai Wang: Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Yali Huang: Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Xuexing Luo: Faculty of Humanities and Arts, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Xin Lai: Department of Traditional Chinese Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong Province, Guangzhou, 510655, China
Lili Yu: State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Ziming Zhao: State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Aijia Zhang: Faculty of Humanities and Arts, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Hong Li: Faculty of Humanities and Arts, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China
Guanghui Huang: Faculty of Humanities and Arts, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Corresponding author.
Yu Li: State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Corresponding author. Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China.
Jue Wang: State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangzhou, Guangdong Province, China; Corresponding author. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China.
Qibiao Wu: State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China; Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangzhou, Guangdong Province, China; Corresponding author. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau SAR, China.

Journal volume & issue: Vol. 10, no. 19
p. e39026

Abstract

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This study summarizes the significance of microRNA-134 (miRNA-134) in the pathophysiology, diagnosis, and treatment of depression, a disease still under investigation due to its complexity. miRNA-134 is an endogenous short non-coding RNA that can bind to the 3′ untranslated region (3′UTR) of miRNA-134, inhibiting gene translation and showing great potential in the regulation of mood, synaptic plasticity, and neuronal function. This study included 15 articles retrieved from four English-language databases: PubMed, Embase, The Cochrane Library, and Web of Science, and three Chinese literature databases: CNKI, Wanfang, and Chinese Science and Technology Periodical Database (VIP).We evaluated each of the 15 articles using the Critical Appraisal Skills Program (CASP) tool.The standard integrates analyzes of genomic, transcriptomic, neuroimaging, and behavioral data analyses related to miRNA-134 and depression. A multidimensional framework based on standardized criteria was used for quality assessment. The main findings indicate that miRNA-134 significantly affects synaptic plasticity and neurotransmitter regulation, in particular the synthesis and release of serotonin and dopamine. miRNA-134 shows high sensitivity and specificity as a biomarker for the diagnosis of depression and has therapeutic potential for the targeted treatment of depression. miRNA-134 plays a crucial role in the pathogenesis of depression, providing valuable insights for early diagnosis and the development of targeted therapeutic strategies. This work highlights the potential of miRNA-134 as a focal point for advancing personalized medicine approaches for depression.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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