Biomedicines (Feb 2023)

Multilineage-Differentiating Stress-Enduring Cells (Muse Cells): The Future of Human and Veterinary Regenerative Medicine

  • María Gemma Velasco,
  • Katy Satué,
  • Deborah Chicharro,
  • Emma Martins,
  • Marta Torres-Torrillas,
  • Pau Peláez,
  • Laura Miguel-Pastor,
  • Ayla Del Romero,
  • Elena Damiá,
  • Belén Cuervo,
  • José María Carrillo,
  • Ramón Cugat,
  • Joaquín Jesús Sopena,
  • Mónica Rubio

DOI
https://doi.org/10.3390/biomedicines11020636
Journal volume & issue
Vol. 11, no. 2
p. 636

Abstract

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In recent years, several studies have been conducted on Muse cells mainly due to their pluripotency, high tolerance to stress, self-renewal capacity, ability to repair DNA damage and not being tumoral. Additionally, since these stem cells can be isolated from different tissues in the adult organism, obtaining them is not considered an ethical problem, providing an advantage over embryonic stem cells. Regarding their therapeutic potential, few studies have reported clinical applications in the treatment of different diseases, such as aortic aneurysm and chondral injuries in the mouse or acute myocardial infarction in the swine, rabbit, sheep and in humans. This review aims to describe the characterization of Muse cells, show their biological characteristics, explain the differences between Muse cells and mesenchymal stem cells, and present their contribution to the treatment of some diseases.

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