Nature Communications (Apr 2021)
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
- Cajsa Davegårdh,
- Johanna Säll,
- Anna Benrick,
- Christa Broholm,
- Petr Volkov,
- Alexander Perfilyev,
- Tora Ida Henriksen,
- Yanling Wu,
- Line Hjort,
- Charlotte Brøns,
- Ola Hansson,
- Maria Pedersen,
- Jens U. Würthner,
- Klaus Pfeffer,
- Emma Nilsson,
- Allan Vaag,
- Elisabet Stener-Victorin,
- Karolina Pircs,
- Camilla Scheele,
- Charlotte Ling
Affiliations
- Cajsa Davegårdh
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- Johanna Säll
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- Anna Benrick
- Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Christa Broholm
- Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet
- Petr Volkov
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- Alexander Perfilyev
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- Tora Ida Henriksen
- The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Yanling Wu
- Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg
- Line Hjort
- Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet
- Charlotte Brøns
- Diabetes and Bone-metabolic Research Unit, Department of Endocrinology, Rigshospitalet
- Ola Hansson
- Genomics, Diabetes and Endocrinology Unit, Department of Clinical Sciences, Lund University
- Maria Pedersen
- The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Jens U. Würthner
- ADC Therapeutics, Biopole
- Klaus Pfeffer
- Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf
- Emma Nilsson
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- Allan Vaag
- Steno Diabetes Center Copenhagen
- Elisabet Stener-Victorin
- Department of Physiology and Pharmacology, Karolinska Institutet
- Karolina Pircs
- Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University
- Camilla Scheele
- The Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen
- Charlotte Ling
- Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Scania University Hospital
- DOI
- https://doi.org/10.1038/s41467-021-22068-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Insulin resistance and lower muscle strength in relation to mass are hallmarks of type 2 diabetes. Here, the authors report alterations in muscle stem cells from individuals with type 2 diabetes that may contribute to these phenotypes through VPS39 mediated effects on autophagy and epigenetics.
