IMPLANTAÇÃO DE METODOLOGIAS PARA ANÁLISE COMPARATIVA DE SEQUÊNCIAS GENÔMICAS RELACIONADAS AO CÂNCER DE PELE

Abstract

Exposure to ultraviolet rays has caused the increased incidence of skin cancer, usually associated with changes in the DNA structure. Genome databases allow public access to DNA sequences that can be compared and analyzed, such as the P53 gene, related to the type of skin cancer with the highest incidence. This research aims to establish methodologies for comparative analysis of nucleotide sequences for the assessment of environmental impacts. Investigations aiming to determine the most frequent mutations in the gene databases populations from countries with contrasting differences are being held. The original gene sequence is compared Recebido em: 10/08/2014_ Aprovado em: 28/08/2014 Sequências genômicas e câncer de pele 2 Colloquium Exactarum, v. 6, n.3, Set-Out. 2014, p.01 –09. DOI: 10.5747/ce.2014.v06.n3.e084 with mutant sequences described in patients with skin cancer through a bioinformatics tool. Comparative studies will be conducted in order to establish correlations between the most frequent mutations and environmental factors that may be related to the origin of the mutations.

Keywords

• bioinformatics
• mutations
• genomic databank
• skin cancer
• p53 gene