Dynamic methylation of histone H3K18 in differentiating Theileria parasites

Kevin Cheeseman; Guillaume Jannot; Nelly Lourenço; Marie Villares; Jérémy Berthelet; Teresa Calegari-Silva; Juliette Hamroune; Franck Letourneur; Fernando Rodrigues-Lima; Jonathan B. Weitzman

doi:10.1038/s41467-021-23477-2

Nature Communications (May 2021)

Dynamic methylation of histone H3K18 in differentiating Theileria parasites

Kevin Cheeseman,
Guillaume Jannot,
Nelly Lourenço,
Marie Villares,
Jérémy Berthelet,
Teresa Calegari-Silva,
Juliette Hamroune,
Franck Letourneur,
Fernando Rodrigues-Lima,
Jonathan B. Weitzman

Affiliations

Kevin Cheeseman: Université de Paris, Epigenetics and Cell Fate, CNRS
Guillaume Jannot: Université de Paris, Epigenetics and Cell Fate, CNRS
Nelly Lourenço: Université de Paris, Epigenetics and Cell Fate, CNRS
Marie Villares: Université de Paris, Epigenetics and Cell Fate, CNRS
Jérémy Berthelet: Université de Paris, Epigenetics and Cell Fate, CNRS
Teresa Calegari-Silva: Université de Paris, Epigenetics and Cell Fate, CNRS
Juliette Hamroune: Université de Paris, Institut Cochin, Inserm, CNRS
Franck Letourneur: Université de Paris, Institut Cochin, Inserm, CNRS
Fernando Rodrigues-Lima: Université de Paris, Functional and Adaptive Biology, CNRS
Jonathan B. Weitzman: Université de Paris, Epigenetics and Cell Fate, CNRS

DOI: https://doi.org/10.1038/s41467-021-23477-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Post-translational modifications (PTM) of histones are important for epigenetic regulation in mammals. Here, Cheeseman et al. report dynamic changes in H3K18 PTM during the differentiation stages of Theileria parasites and they identify a SET-domain methyltransferase (TaSETup1) as the relevant enzyme promoting this modification.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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