Endocrine Regulations (Oct 2019)

Effect of glucose deprivation on the expression of genes encoding glucocorticoid receptor and some related factors in ERN1-knockdown U87 glioma cells

  • Riabovol Olena O.,
  • Tsymbal Dariia O.,
  • Minchenko Dmytro O.,
  • Lebid-Biletska Kateryna M.,
  • Sliusar Myroslava Y.,
  • Rudnytska Olha V.,
  • Minchenko Oleksandr H.

DOI
https://doi.org/10.2478/enr-2019-0024
Journal volume & issue
Vol. 53, no. 4
pp. 237 – 249

Abstract

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Objective. The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1) for evaluation of their possible significance in the control of glioma growth through endoplasmic reticulum stress signaling mediated by IRE1 and glucose deprivation.

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