Bagcilar Medical Bulletin (Mar 2022)

The Role of MPV-to-Lymphocyte Ratio and MPVto- Platelet Ratio in Predicting Mortality in Patients with Acute Myocardial Infarction

  • Serkan Karahan,
  • Fahrettin Katkat,
  • Sinan Varol,
  • Mehmet Fırat Yıldırım,
  • Orhan İnce,
  • İrfan Şahin,
  • Ertuğrul Okuyan

DOI
https://doi.org/10.4274/BMB.galenos.2022.2021-10-112
Journal volume & issue
Vol. 7, no. 1
pp. 32 – 37

Abstract

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Objective:In this study, we aimed to evaluate the relationship between the laboratory parameters of mean platelet volume/lymphocyte ratio (MPVLR) and mean platelet volume/platelet ratio (MPVPR) with prognosis and mortality in patients with hospitalized glomerular filtration rate (GFR) <60 and a diagnosis of acute myocardial infarction (AMI).Method:This study was designed as a retrospective cohort study. Two hundred myocardial infarction (MI) patients over the age of 18 years and with GFR <60, who were hospitalized in our hospital between January 01, 2018 and January 01, 2021, were included in the study. The patients were divided into 2 groups, as the survivor and mortality groups. The two groups were compared in terms of demographic characteristics and clinical data (symptoms, comorbidities, laboratory findings, GFR, coronary angiography, drugs used and complications). MPVLR was found by dividing the mean platelet volume to lymphocyte count. MPVPR was found by dividing the mean platelet volume to platelet count.Results:The mean age of the survivor group was 64.3±10.4. In the mortality group, the mean age was 70.02±9.3. MPVLR levels were statistically significantly higher in the mortality group (8.39±5.9) compared to the survivor group (6.58±5.4) (p=0.011). However, MPVPR levels were statistically significantly lower in the mortality group (0.041±0.01) compared to the survivor group (0.044±0.01) (p=0.048). According to the results of ROC analysis in patients with mortality, sensitivity was 50.0% and specificity was 68.6% for MPVLR (p=0.010); sensitivity was 41.0% and specificity was 47.9% for MPVPR. The risk factors found to be significantly associated with mortality in the regression analysis included MPVPR [β: 0.045, odds ratio (95% confidence interval): 0.945 (0.899- 1.001), p=0.032].Conclusion:As inexpensive and easily available new inflammatory markers, MPVLR and MPVPR were significantly higher in patients with GFR <60 and in those who died from AMI. In addition, MPVLR and MPVPR could predict mortality from MI.

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