Nature Communications (Jun 2016)

Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases

  • Urszula M. McCaughan,
  • Uma Jayachandran,
  • Vadim Shchepachev,
  • Zhuo Angel Chen,
  • Juri Rappsilber,
  • David Tollervey,
  • Atlanta G. Cook

DOI
https://doi.org/10.1038/ncomms11789
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 8

Abstract

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Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn.