Nature Communications (Jul 2021)

MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery

  • David J. Wooten,
  • Christian T. Meyer,
  • Alexander L. R. Lubbock,
  • Vito Quaranta,
  • Carlos F. Lopez

DOI
https://doi.org/10.1038/s41467-021-24789-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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The lack of a unifying metric characterizing combinatorial drug interactions has impeded the development of combinatorial therapies. Here, the authors present MuSyC, a consensus synergy metric that overcomes several caveats associated with other, popular metrics.