Nature Communications (Aug 2016)

PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

  • Jinxue He,
  • Zhong Zhang,
  • Meng Ouyang,
  • Fan Yang,
  • Hongbo Hao,
  • Kristy L. Lamb,
  • Jingyi Yang,
  • Yuxin Yin,
  • Wen H. Shen

DOI
https://doi.org/10.1038/ncomms12355
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.