Nature Communications (Nov 2020)

Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

  • Katla Kristjánsdóttir,
  • Alexis Dziubek,
  • Hyun Min Kang,
  • Hojoong Kwak

DOI
https://doi.org/10.1038/s41467-020-19829-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the bipartite architecture of enhancers.