Two forms of death in ageing Caenorhabditis elegans

Yuan Zhao; Ann F. Gilliat; Matthias Ziehm; Mark Turmaine; Hongyuan Wang; Marina Ezcurra; Chenhao Yang; George Phillips; David McBay; William B. Zhang; Linda Partridge; Zachary Pincus; David Gems

doi:10.1038/ncomms15458

Nature Communications (May 2017)

Two forms of death in ageing Caenorhabditis elegans

Yuan Zhao,
Ann F. Gilliat,
Matthias Ziehm,
Mark Turmaine,
Hongyuan Wang,
Marina Ezcurra,
Chenhao Yang,
George Phillips,
David McBay,
William B. Zhang,
Linda Partridge,
Zachary Pincus,
David Gems

Affiliations

Yuan Zhao: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Ann F. Gilliat: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Matthias Ziehm: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Mark Turmaine: Department of Cell and Developmental Biology, University College London
Hongyuan Wang: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Marina Ezcurra: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Chenhao Yang: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
George Phillips: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
David McBay: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
William B. Zhang: Department of Genetics, Washington University in St Louis
Linda Partridge: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London
Zachary Pincus: Department of Genetics, Washington University in St Louis
David Gems: Department of Genetics, Institute of Healthy Ageing, Evolution and Environment, University College London

DOI: https://doi.org/10.1038/ncomms15458
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

Read online

Despite its wide use in ageing research, the contribution of specific age-associated pathologies toC. elegansmortality is not well understood. Here the authors identify two types of death in worms, with either a swollen or a shrunken pharynx, that are differentially affected by age and mutations that extend worm lifespan.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal