NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary

Audrey Ferrand; Ziad Al Nabhani; Núria Solà Tapias; Emmanuel Mas; Jean-Pierre Hugot; Frédérick Barreau

Cellular and Molecular Gastroenterology and Hepatology (Jan 2019)

NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary

Audrey Ferrand,
Ziad Al Nabhani,
Núria Solà Tapias,
Emmanuel Mas,
Jean-Pierre Hugot,
Frédérick Barreau

Affiliations

Audrey Ferrand: Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France
Ziad Al Nabhani: Laboratoire Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France; INSERM, UMR 1149, Paris, France
Núria Solà Tapias: Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France
Emmanuel Mas: Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France; Unité de Gastroentérologie, Hépatologie, Maladies Héréditaires du Métabolisme et Nutrition, Hôpital des Enfants, Toulouse, France
Jean-Pierre Hugot: Laboratoire Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France; INSERM, UMR 1149, Paris, France; Assistance Publique Hôpitaux de Paris, Hôpital Robert Debré, Paris, France
Frédérick Barreau: Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France; Correspondence Address correspondence to: Frédérick Barreau, PhD, INSERM, UMR 1220, Institut de Recherche en Santé Digestive, Toulouse, France. fax: (33) 5-62-74-45-58.

Journal volume & issue: Vol. 7, no. 2
pp. 357 – 369

Abstract

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Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development. Keywords: Nod2, Cancer, Colitis, Gut, Epithelial cells

Published in Cellular and Molecular Gastroenterology and Hepatology

ISSN: 2352-345X (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.journals.elsevier.com/cellular-and-molecular-gastroenterology-and-hepatology/

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