Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Nairie Michaelian; Anastasiia Sadybekov; Élie Besserer-Offroy; Gye Won Han; Harini Krishnamurthy; Beata A. Zamlynny; Xavier Fradera; Phieng Siliphaivanh; Jeremy Presland; Kerrie B. Spencer; Stephen M. Soisson; Petr Popov; Philippe Sarret; Vsevolod Katritch; Vadim Cherezov

doi:10.1038/s41467-021-23149-1

Nature Communications (May 2021)

Structural insights on ligand recognition at the human leukotriene B4 receptor 1

Nairie Michaelian,
Anastasiia Sadybekov,
Élie Besserer-Offroy,
Gye Won Han,
Harini Krishnamurthy,
Beata A. Zamlynny,
Xavier Fradera,
Phieng Siliphaivanh,
Jeremy Presland,
Kerrie B. Spencer,
Stephen M. Soisson,
Petr Popov,
Philippe Sarret,
Vsevolod Katritch,
Vadim Cherezov

Affiliations

Nairie Michaelian: Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California
Anastasiia Sadybekov: Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California
Élie Besserer-Offroy: Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke
Gye Won Han: Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California
Harini Krishnamurthy: Merck Research Laboratories, Merck & Co., Inc.
Beata A. Zamlynny: Merck Research Laboratories, Merck & Co., Inc.
Xavier Fradera: Merck Research Laboratories, Merck & Co., Inc.
Phieng Siliphaivanh: Merck Research Laboratories, Merck & Co., Inc.
Jeremy Presland: Merck Research Laboratories, Merck & Co., Inc.
Kerrie B. Spencer: Merck Research Laboratories, Merck & Co., Inc.
Stephen M. Soisson: Merck Research Laboratories, Merck & Co., Inc.
Petr Popov: Center for Computational and Data Intensive Science and Engineering, Skolkovo Institute of Science and Technology
Philippe Sarret: Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke
Vsevolod Katritch: Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California
Vadim Cherezov: Bridge Institute, USC Michelson Center for Convergent Bioscience, University of Southern California

DOI: https://doi.org/10.1038/s41467-021-23149-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Human leukotriene B4 receptors (BLT1 and BLT2) are members of the GPCR superfamily that respond to a potent pro-inflammatory lipid and chemoattractant LTB4. Here authors determined a crystal structure of the human BLT1 in complex with a selective antagonist MK-D-046 and provide insights into hBLT1 ligand recognition and its mechanism of action.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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