Advances in hematopoietic stem cell transplantation for autoimmune diseases

Yuxi Xu; Xiaoqi Wang; Ziyi Hu; Ruihao Huang; Guancui Yang; Rui Wang; Shijie Yang; Liyan Guo; Qingxiao Song; Jin Wei; Xi Zhang

Heliyon (Oct 2024)

Advances in hematopoietic stem cell transplantation for autoimmune diseases

Yuxi Xu,
Xiaoqi Wang,
Ziyi Hu,
Ruihao Huang,
Guancui Yang,
Rui Wang,
Shijie Yang,
Liyan Guo,
Qingxiao Song,
Jin Wei,
Xi Zhang

Affiliations

Yuxi Xu: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Xiaoqi Wang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Ziyi Hu: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Ruihao Huang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Guancui Yang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Rui Wang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China
Shijie Yang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Liyan Guo: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China
Qingxiao Song: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China; Corresponding author. Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China.
Jin Wei: Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China; Corresponding author. Department of Hematology, Affiliated Hospital of North Sichuan Medical College, Sichuan, 637000, China.
Xi Zhang: Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China; Chongqing Key Laboratory of Hematology and Microenvironment, Chongqing, 400037, China; Jinfeng Laboratory, Chongqing, 401329, China; Corresponding author. Medical Center of Hematology, Xinqiao Hospital of Army Medical University, Chongqing, 400037, China.

Journal volume & issue: Vol. 10, no. 20
p. e39302

Abstract

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Autoimmune diseases (ADs) are a collection of immunological disorders in which the immune system responds to self-antigens by producing autoantibodies or self-sensitized cells. Current treatments are unable to cure ADs, and achieving long-term drug-free remission remains a challenging task. Hematopoietic stem cell transplantation (HSCT) stands out from other therapies by specifically targeting ADs that target various cell subpopulations, demonstrating notable therapeutic benefits and resulting in sustained drug-free remission. Since different ADs have distinct mechanisms of action, the comprehensive understanding of how HSCT works in treating ADs is crucial. This review provides a detailed overview of the latest research and clinical applications of HSCT in treating ADs, offering new insights for clinicians aiming to optimize its use for ADs management.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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