Strobilurin biosynthesis in Basidiomycete fungi

Risa Nofiani; Kate de Mattos-Shipley; Karen E. Lebe; Li-Chen Han; Zafar Iqbal; Andrew M. Bailey; Christine L. Willis; Thomas J. Simpson; Russell J. Cox

doi:10.1038/s41467-018-06202-4

Nature Communications (Sep 2018)

Strobilurin biosynthesis in Basidiomycete fungi

Risa Nofiani,
Kate de Mattos-Shipley,
Karen E. Lebe,
Li-Chen Han,
Zafar Iqbal,
Andrew M. Bailey,
Christine L. Willis,
Thomas J. Simpson,
Russell J. Cox

Affiliations

Risa Nofiani: School of Chemistry, University of Bristol
Kate de Mattos-Shipley: School of Chemistry, University of Bristol
Karen E. Lebe: Institute for Organic Chemistry, Leibniz Universität Hannover
Li-Chen Han: School of Chemistry, University of Bristol
Zafar Iqbal: School of Chemistry, University of Bristol
Andrew M. Bailey: School of Biological Sciences, University of Bristol
Christine L. Willis: School of Chemistry, University of Bristol
Thomas J. Simpson: School of Chemistry, University of Bristol
Russell J. Cox: School of Chemistry, University of Bristol

DOI: https://doi.org/10.1038/s41467-018-06202-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Strobilurins are fungal metabolites that inspired the creation of β-methoxyacrylate agricultural fungicides. Here, Nofiani et al. identify the strobilurin biosynthesis gene cluster, encoding a polyketide synthase as well as an FAD-dependent oxygenase for an oxidative rearrangement leading to β-methoxyacrylate formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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