Nature Communications (Dec 2022)
Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion
- Hiroyuki Kawai,
- Youcef Bouchekioua,
- Naoya Nishitani,
- Kazuhei Niitani,
- Shoma Izumi,
- Hinako Morishita,
- Chihiro Andoh,
- Yuma Nagai,
- Masashi Koda,
- Masako Hagiwara,
- Koji Toda,
- Hisashi Shirakawa,
- Kazuki Nagayasu,
- Yu Ohmura,
- Makoto Kondo,
- Katsuyuki Kaneda,
- Mitsuhiro Yoshioka,
- Shuji Kaneko
Affiliations
- Hiroyuki Kawai
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Youcef Bouchekioua
- Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Naoya Nishitani
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Kazuhei Niitani
- Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
- Shoma Izumi
- Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
- Hinako Morishita
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Chihiro Andoh
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Yuma Nagai
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Masashi Koda
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Masako Hagiwara
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Koji Toda
- Department of Psychology, Keio University
- Hisashi Shirakawa
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Kazuki Nagayasu
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- Yu Ohmura
- Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Makoto Kondo
- Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka Metropolitan University
- Katsuyuki Kaneda
- Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
- Mitsuhiro Yoshioka
- Department of Neuropharmacology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
- Shuji Kaneko
- Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-022-35346-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pathway was rewarding.
