Frontiers in Immunology (Jan 2024)

Clinical research on RSV prevention in children and pregnant women: progress and perspectives

  • Xuejia Gong,
  • Erdan Luo,
  • Li Fan,
  • Wanggang Zhang,
  • Yan Yang,
  • Yuhua Du,
  • Xiao Yang,
  • Shasha Xing

DOI
https://doi.org/10.3389/fimmu.2023.1329426
Journal volume & issue
Vol. 14

Abstract

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Respiratory syncytial virus (RSV) is a significant causative agent of bronchitis and pneumonia in infants and children. The identification and structural analysis of the surface fusion glycoprotein of RSV represents a pivotal advancement in the development of RSV prevention. This review provides a comprehensive summary of RSV monoclonal antibody (mAb) and vaccine clinical trials registered on ClinicalTrials.gov, emphasizing on the classification, name, target, phase, clinical outcomes, and safety data of RSV vaccination in newborns, infants and children. We also discuss the characteristics of the types of RSV vaccines for maternal immunity and summarize the current clinical research progress of RSV vaccination in pregnant women and their protective efficacy in infants. This review will provide new ideas for the development of RSV prevention for children in the future.

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