Dopamine D2 receptor regulates cortical synaptic pruning in rodents

Ya-Qiang Zhang; Wei-Peng Lin; Li-Ping Huang; Bing Zhao; Cheng-Cheng Zhang; Dong-Min Yin

doi:10.1038/s41467-021-26769-9

Nature Communications (Nov 2021)

Dopamine D2 receptor regulates cortical synaptic pruning in rodents

Ya-Qiang Zhang,
Wei-Peng Lin,
Li-Ping Huang,
Bing Zhao,
Cheng-Cheng Zhang,
Dong-Min Yin

Affiliations

Ya-Qiang Zhang: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University
Wei-Peng Lin: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University
Li-Ping Huang: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University
Bing Zhao: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University
Cheng-Cheng Zhang: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University
Dong-Min Yin: Key Laboratory of Brain Functional Genomics, Ministry of Education and Shanghai, School of Life Science, East China Normal University

DOI: https://doi.org/10.1038/s41467-021-26769-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Synaptic pruning is important during development and synaptic plasticity. Here, the authors show that the dopamine D2 receptor (Drd2) in the anterior cingulate cortex regulates synaptic pruning, affecting LTD and behaviour in transgenic rats.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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