Nature Communications (May 2021)
Critical role of interferons in gastrointestinal injury repair
- Constance McElrath,
- Vanessa Espinosa,
- Jian-Da Lin,
- Jianya Peng,
- Raghavendra Sridhar,
- Orchi Dutta,
- Hsiang-Chi Tseng,
- Sergey V. Smirnov,
- Heidi Risman,
- Marvin J. Sandoval,
- Viralkumar Davra,
- Yun-Juan Chang,
- Brian P. Pollack,
- Raymond B. Birge,
- Mark Galan,
- Amariliz Rivera,
- Joan E. Durbin,
- Sergei V. Kotenko
Affiliations
- Constance McElrath
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Vanessa Espinosa
- Pediatrics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Jian-Da Lin
- School of Graduate Studies, Rutgers—The State University of New Jersey
- Jianya Peng
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Raghavendra Sridhar
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Orchi Dutta
- School of Graduate Studies, Rutgers—The State University of New Jersey
- Hsiang-Chi Tseng
- School of Graduate Studies, Rutgers—The State University of New Jersey
- Sergey V. Smirnov
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Heidi Risman
- Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers—The State University of New Jersey
- Marvin J. Sandoval
- Department of Pathology, New York University School of Medicine
- Viralkumar Davra
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Yun-Juan Chang
- Office of Advance Research Computing, Rutgers—The State University of New Jersey
- Brian P. Pollack
- Atlanta Veterans Affairs Medical Center
- Raymond B. Birge
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Mark Galan
- Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers—The State University of New Jersey
- Amariliz Rivera
- Pediatrics, New Jersey Medical School, Rutgers—The State University of New Jersey
- Joan E. Durbin
- Pathology, Immunology and Laboratory Medicine, New Jersey Medical School, Rutgers—The State University of New Jersey
- Sergei V. Kotenko
- Department of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers—The State University of New Jersey
- DOI
- https://doi.org/10.1038/s41467-021-22928-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Despite being prevalent yet well studied, ulcerative colitis still has poorly characterized pathophysiology. Here the authors use mouse colitis models to find that type I and III interferon (IFN) both contribute to ameliorating the disease, with IFN signaling in either the epithelial or hematopoietic compartment sufficient for this protective effect.
