Nature Communications (Jun 2019)
Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M
- Hajime Abe,
- Norihiko Takeda,
- Takayuki Isagawa,
- Hiroaki Semba,
- Satoshi Nishimura,
- Masaki Suimye Morioka,
- Yu Nakagama,
- Tatsuyuki Sato,
- Katsura Soma,
- Katsuhiro Koyama,
- Masaki Wake,
- Manami Katoh,
- Masataka Asagiri,
- Michael L. Neugent,
- Jung-whan Kim,
- Christian Stockmann,
- Tomo Yonezawa,
- Ryo Inuzuka,
- Yasushi Hirota,
- Koji Maemura,
- Takeshi Yamashita,
- Kinya Otsu,
- Ichiro Manabe,
- Ryozo Nagai,
- Issei Komuro
Affiliations
- Hajime Abe
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Norihiko Takeda
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Takayuki Isagawa
- Graduate School of Biomedical Science, Nagasaki University
- Hiroaki Semba
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Satoshi Nishimura
- PRESTO, JST
- Masaki Suimye Morioka
- Depertment of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University
- Yu Nakagama
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Tatsuyuki Sato
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Katsura Soma
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Katsuhiro Koyama
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masaki Wake
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Manami Katoh
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- Masataka Asagiri
- Department of Pathobiology, Graduate School of Pharmaceutical Sciences, Nagoya City University
- Michael L. Neugent
- Department of Biological Sciences, The University of Texas at Dallas
- Jung-whan Kim
- Department of Biological Sciences, The University of Texas at Dallas
- Christian Stockmann
- Institute of Anatomy, University of Zurich
- Tomo Yonezawa
- Center for Therapeutic Innovation, Gene Research Center, Center for Frontier Life Sciences, Nagasaki University, Graduate School of Biomedical Sciences
- Ryo Inuzuka
- Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
- Yasushi Hirota
- Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo
- Koji Maemura
- Graduate School of Biomedical Science, Nagasaki University
- Takeshi Yamashita
- Department of Cardiovascular Medicine, The Cardiovascular Institute
- Kinya Otsu
- The School of Cardiovascular Medicine and Sciences, King’s College London British Heart Foundation Centre of Excellence
- Ichiro Manabe
- Department of Disease Biology and Molecular Medicine, Graduate School of Medicine, Chiba University
- Ryozo Nagai
- Jichi Medical University
- Issei Komuro
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-019-10859-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Fibrosis is a hallmark of several cardiac pathologies and its underlying mechanisms are still poorly defined. Here the authors show that macrophage hypoxia signaling following transverse aortic constriction in mice suppresses the activation of cardiac fibroblasts by secreting oncostatin M.
