Nature Communications (Apr 2020)
LGR5 marks targetable tumor-initiating cells in mouse liver cancer
- Wanlu Cao,
- Meng Li,
- Jiaye Liu,
- Shaoshi Zhang,
- Lisanne Noordam,
- Monique M. A. Verstegen,
- Ling Wang,
- Buyun Ma,
- Shan Li,
- Wenshi Wang,
- Michiel Bolkestein,
- Michael Doukas,
- Kan Chen,
- Zhongren Ma,
- Marco Bruno,
- Dave Sprengers,
- Jaap Kwekkeboom,
- Luc J. W. van der Laan,
- Ron Smits,
- Maikel P. Peppelenbosch,
- Qiuwei Pan
Affiliations
- Wanlu Cao
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Meng Li
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Jiaye Liu
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Shaoshi Zhang
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Lisanne Noordam
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Monique M. A. Verstegen
- Department of Surgery, Erasmus MC-University Medical Center
- Ling Wang
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Buyun Ma
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Shan Li
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Wenshi Wang
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Michiel Bolkestein
- Department of Surgery, Erasmus MC-University Medical Center
- Michael Doukas
- Department of Pathology, Erasmus MC-University Medical Center
- Kan Chen
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Zhongren Ma
- Biomedical Research Center, Northwest Minzu University
- Marco Bruno
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Dave Sprengers
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Jaap Kwekkeboom
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Luc J. W. van der Laan
- Department of Surgery, Erasmus MC-University Medical Center
- Ron Smits
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Maikel P. Peppelenbosch
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- Qiuwei Pan
- Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-15846-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Cancer stem cells (CSCs) are thought to be the main drivers for disease progression and treatment resistance in liver cancer. This study identifies the LGR5+ compartment as an important CSC population, representing a viable therapeutic target for combating liver cancer.
