Efficient Synthesis of New Fluorinated Building Blocks by means of Hydroformylation

Abstract

Hydroformylation of fluorinated alkenes is an efficient method for the preparation of fluorinated functionalized building blocks for the synthesis of biologically active target structures. In this article we summarize known hydroformylation reactions of fluorinated olefins and we add new results from our research groups. Particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.

Keywords

• Aldehydes
• Alkenes
• Hydroformylation
• Organofluorides
• Rhodium