Fractional re-distribution among cell motility states during ageing

Jude M. Phillip; Nahuel Zamponi; Madonna P. Phillip; Jena Daya; Shaun McGovern; Wadsworth Williams; Katherine Tschudi; Hasini Jayatilaka; Pei-Hsun Wu; Jeremy Walston; Denis Wirtz

doi:10.1038/s42003-020-01605-w

Communications Biology (Jan 2021)

Fractional re-distribution among cell motility states during ageing

Jude M. Phillip,
Nahuel Zamponi,
Madonna P. Phillip,
Jena Daya,
Shaun McGovern,
Wadsworth Williams,
Katherine Tschudi,
Hasini Jayatilaka,
Pei-Hsun Wu,
Jeremy Walston,
Denis Wirtz

Affiliations

Jude M. Phillip: Departments of Biomedical Engineering, Johns Hopkins University
Nahuel Zamponi: Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine
Madonna P. Phillip: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Jena Daya: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Shaun McGovern: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Wadsworth Williams: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Katherine Tschudi: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Hasini Jayatilaka: AtlasXomics Inc.
Pei-Hsun Wu: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University
Jeremy Walston: Department of Medicine, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine
Denis Wirtz: Department of Chemical and Biomolecular Engineering, Institute for NanoBiotechnology (INBT), Johns Hopkins University

DOI: https://doi.org/10.1038/s42003-020-01605-w
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 9

Abstract

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Phillip and colleagues use dermal fibroblasts from a range of donors to quantify cell motility in ageing cells. They show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional redistribution among motility states.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal