Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Elwood A. Mullins; Jonathan Dorival; Gong-Li Tang; Dale L. Boger; Brandt F. Eichman

doi:10.1038/s41467-021-27284-7

Nature Communications (Nov 2021)

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites

Elwood A. Mullins,
Jonathan Dorival,
Gong-Li Tang,
Dale L. Boger,
Brandt F. Eichman

Affiliations

Elwood A. Mullins: Department of Biological Sciences, Vanderbilt University
Jonathan Dorival: Department of Biological Sciences, Vanderbilt University
Gong-Li Tang: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Dale L. Boger: Department of Chemistry, The Scripps Research Institute
Brandt F. Eichman: Department of Biological Sciences, Vanderbilt University

DOI: https://doi.org/10.1038/s41467-021-27284-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products. Here, the authors provide evidence that cellular self-resistance is enabled by reduced affinity of the glycosylases for the excision products of the corresponding DNA lesions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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