Nature Communications (Jun 2022)

FANCM promotes class I interfering crossovers and suppresses class II non-interfering crossovers in wheat meiosis

  • Stuart D. Desjardins,
  • James Simmonds,
  • Inna Guterman,
  • Kostya Kanyuka,
  • Amanda J. Burridge,
  • Andrew J. Tock,
  • Eugenio Sanchez-Moran,
  • F. Chris H. Franklin,
  • Ian R. Henderson,
  • Keith J. Edwards,
  • Cristobal Uauy,
  • James D. Higgins

DOI
https://doi.org/10.1038/s41467-022-31438-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The FANCM helicase functions in limiting crossovers (COs) by unwinding inter-homolog repair intermediates. Here, the authors generate null mutants of fancm in tetraploid and hexaploid wheat and show that FANCM promotes class I interfering COs and suppresses class II noninterfering COs in wheat meiosis.