Nature Communications (Aug 2021)
Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children
- Noam D. Beckmann,
- Phillip H. Comella,
- Esther Cheng,
- Lauren Lepow,
- Aviva G. Beckmann,
- Scott R. Tyler,
- Konstantinos Mouskas,
- Nicole W. Simons,
- Gabriel E. Hoffman,
- Nancy J. Francoeur,
- Diane Marie Del Valle,
- Gurpawan Kang,
- Anh Do,
- Emily Moya,
- Lillian Wilkins,
- Jessica Le Berichel,
- Christie Chang,
- Robert Marvin,
- Sharlene Calorossi,
- Alona Lansky,
- Laura Walker,
- Nancy Yi,
- Alex Yu,
- Jonathan Chung,
- Matthew Hartnett,
- Melody Eaton,
- Sandra Hatem,
- Hajra Jamal,
- Alara Akyatan,
- Alexandra Tabachnikova,
- Lora E. Liharska,
- Liam Cotter,
- Brian Fennessy,
- Akhil Vaid,
- Guillermo Barturen,
- Hardik Shah,
- Ying-chih Wang,
- Shwetha Hara Sridhar,
- Juan Soto,
- Swaroop Bose,
- Kent Madrid,
- Ethan Ellis,
- Elyze Merzier,
- Konstantinos Vlachos,
- Nataly Fishman,
- Manying Tin,
- Melissa Smith,
- Hui Xie,
- Manishkumar Patel,
- Kai Nie,
- Kimberly Argueta,
- Jocelyn Harris,
- Neha Karekar,
- Craig Batchelor,
- Jose Lacunza,
- Mahlet Yishak,
- Kevin Tuballes,
- Ieisha Scott,
- Arvind Kumar,
- Suraj Jaladanki,
- Charuta Agashe,
- Ryan Thompson,
- Evan Clark,
- Bojan Losic,
- Lauren Peters,
- The Mount Sinai COVID-19 Biobank Team,
- Panagiotis Roussos,
- Jun Zhu,
- Wenhui Wang,
- Andrew Kasarskis,
- Benjamin S. Glicksberg,
- Girish Nadkarni,
- Dusan Bogunovic,
- Cordelia Elaiho,
- Sandeep Gangadharan,
- George Ofori-Amanfo,
- Kasey Alesso-Carra,
- Kenan Onel,
- Karen M. Wilson,
- Carmen Argmann,
- Supinda Bunyavanich,
- Marta E. Alarcón-Riquelme,
- Thomas U. Marron,
- Adeeb Rahman,
- Seunghee Kim-Schulze,
- Sacha Gnjatic,
- Bruce D. Gelb,
- Miriam Merad,
- Robert Sebra,
- Eric E. Schadt,
- Alexander W. Charney
Affiliations
- Noam D. Beckmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Phillip H. Comella
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Esther Cheng
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Lauren Lepow
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Aviva G. Beckmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Scott R. Tyler
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Konstantinos Mouskas
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Nicole W. Simons
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Gabriel E. Hoffman
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Nancy J. Francoeur
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Diane Marie Del Valle
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Gurpawan Kang
- Department of Medicine, Division of Surgery, Icahn School of Medicine at Mount Sinai
- Anh Do
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Emily Moya
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Lillian Wilkins
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Jessica Le Berichel
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Christie Chang
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Robert Marvin
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Sharlene Calorossi
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Alona Lansky
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Laura Walker
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Nancy Yi
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Alex Yu
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Jonathan Chung
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Matthew Hartnett
- Icahn School of Medicine at Mount Sinai
- Melody Eaton
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Sandra Hatem
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Hajra Jamal
- Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai
- Alara Akyatan
- Department of of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai
- Alexandra Tabachnikova
- Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai
- Lora E. Liharska
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Liam Cotter
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Brian Fennessy
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Akhil Vaid
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Guillermo Barturen
- Department of Medical Genomics, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government (GENYO)
- Hardik Shah
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Ying-chih Wang
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Shwetha Hara Sridhar
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Juan Soto
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Swaroop Bose
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Kent Madrid
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Ethan Ellis
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Elyze Merzier
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Konstantinos Vlachos
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Nataly Fishman
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Manying Tin
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Melissa Smith
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Hui Xie
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Manishkumar Patel
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Kai Nie
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Kimberly Argueta
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Jocelyn Harris
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Neha Karekar
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Craig Batchelor
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Jose Lacunza
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Mahlet Yishak
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Kevin Tuballes
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Ieisha Scott
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Arvind Kumar
- Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Suraj Jaladanki
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Charuta Agashe
- Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
- Ryan Thompson
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Evan Clark
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Bojan Losic
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Lauren Peters
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- The Mount Sinai COVID-19 Biobank Team
- Panagiotis Roussos
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Jun Zhu
- Icahn School of Medicine at Mount Sinai
- Wenhui Wang
- Icahn School of Medicine at Mount Sinai
- Andrew Kasarskis
- Icahn School of Medicine at Mount Sinai
- Benjamin S. Glicksberg
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Girish Nadkarni
- Mount Sinai COVID Informatics Center
- Dusan Bogunovic
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Cordelia Elaiho
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Sandeep Gangadharan
- Departments of Pediatrics, Icahn School of Medicine at Mount Sinai
- George Ofori-Amanfo
- Departments of Pediatrics, Icahn School of Medicine at Mount Sinai
- Kasey Alesso-Carra
- Departments of Pediatrics, Icahn School of Medicine at Mount Sinai
- Kenan Onel
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Karen M. Wilson
- Departments of Pediatrics, Icahn School of Medicine at Mount Sinai
- Carmen Argmann
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Supinda Bunyavanich
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Marta E. Alarcón-Riquelme
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Thomas U. Marron
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Adeeb Rahman
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Seunghee Kim-Schulze
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Sacha Gnjatic
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Bruce D. Gelb
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Miriam Merad
- Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Robert Sebra
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Alexander W. Charney
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-021-24981-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural killer (NK) cell activation and CD8+ T cell exhaustion that are shared with KD patients.
