Nature Communications (Feb 2017)
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
- Philip J. Law,
- Sonja I. Berndt,
- Helen E. Speedy,
- Nicola J. Camp,
- Georgina P. Sava,
- Christine F. Skibola,
- Amy Holroyd,
- Vijai Joseph,
- Nicola J. Sunter,
- Alexandra Nieters,
- Silvia Bea,
- Alain Monnereau,
- David Martin-Garcia,
- Lynn R. Goldin,
- Guillem Clot,
- Lauren R. Teras,
- Inés Quintela,
- Brenda M. Birmann,
- Sandrine Jayne,
- Wendy Cozen,
- Aneela Majid,
- Karin E. Smedby,
- Qing Lan,
- Claire Dearden,
- Angela R. Brooks-Wilson,
- Andrew G. Hall,
- Mark P. Purdue,
- Tryfonia Mainou-Fowler,
- Claire M. Vajdic,
- Graham H. Jackson,
- Pierluigi Cocco,
- Helen Marr,
- Yawei Zhang,
- Tongzhang Zheng,
- Graham G. Giles,
- Charles Lawrence,
- Timothy G. Call,
- Mark Liebow,
- Mads Melbye,
- Bengt Glimelius,
- Larry Mansouri,
- Martha Glenn,
- Karen Curtin,
- W Ryan Diver,
- Brian K. Link,
- Lucia Conde,
- Paige M. Bracci,
- Elizabeth A. Holly,
- Rebecca D. Jackson,
- Lesley F. Tinker,
- Yolanda Benavente,
- Paolo Boffetta,
- Paul Brennan,
- Marc Maynadie,
- James McKay,
- Demetrius Albanes,
- Stephanie Weinstein,
- Zhaoming Wang,
- Neil E. Caporaso,
- Lindsay M. Morton,
- Richard K. Severson,
- Elio Riboli,
- Paolo Vineis,
- Roel C. H. Vermeulen,
- Melissa C. Southey,
- Roger L. Milne,
- Jacqueline Clavel,
- Sabine Topka,
- John J. Spinelli,
- Peter Kraft,
- Maria Grazia Ennas,
- Geoffrey Summerfield,
- Giovanni M. Ferri,
- Robert J. Harris,
- Lucia Miligi,
- Andrew R. Pettitt,
- Kari E. North,
- David J. Allsup,
- Joseph F. Fraumeni,
- James R. Bailey,
- Kenneth Offit,
- Guy Pratt,
- Henrik Hjalgrim,
- Chris Pepper,
- Stephen J. Chanock,
- Chris Fegan,
- Richard Rosenquist,
- Silvia de Sanjose,
- Angel Carracedo,
- Martin J. S. Dyer,
- Daniel Catovsky,
- Elias Campo,
- James R. Cerhan,
- James M. Allan,
- Nathanial Rothman,
- Richard Houlston,
- Susan Slager
Affiliations
- Philip J. Law
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Helen E. Speedy
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Nicola J. Camp
- Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine
- Georgina P. Sava
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Christine F. Skibola
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Amy Holroyd
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Vijai Joseph
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Nicola J. Sunter
- Northern Institute for Cancer Research, Newcastle University
- Alexandra Nieters
- Center for Chronic Immunodeficiency, University Medical Center Freiburg
- Silvia Bea
- Institut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic
- Alain Monnereau
- Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE
- David Martin-Garcia
- Institut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic
- Lynn R. Goldin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Guillem Clot
- Institut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic
- Lauren R. Teras
- Epidemiology Research Program, American Cancer Society
- Inés Quintela
- Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER
- Brenda M. Birmann
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Sandrine Jayne
- Ernest and Helen Scott Haematological Research Institute, University of Leicester
- Wendy Cozen
- Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California
- Aneela Majid
- Ernest and Helen Scott Haematological Research Institute, University of Leicester
- Karin E. Smedby
- Department of Medicine Solna, Unit of Clinical Epidemiology, Karolinska Institutet, Hematology Center, Karolinsak University Hospital
- Qing Lan
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Claire Dearden
- The Royal Marsden NHS Foundation Trust
- Angela R. Brooks-Wilson
- Genome Sciences Centre, BC Cancer Agency
- Andrew G. Hall
- Northern Institute for Cancer Research, Newcastle University
- Mark P. Purdue
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Tryfonia Mainou-Fowler
- Haematological Sciences, Medical School, Newcastle University
- Claire M. Vajdic
- Centre for Big Data Research in Health, University of New South Wales
- Graham H. Jackson
- Department of Haematology, Royal Victoria Infirmary
- Pierluigi Cocco
- Department of Public Health, Clinical and Molecular Medicine, University of Cagliari
- Helen Marr
- Northern Institute for Cancer Research, Newcastle University
- Yawei Zhang
- Department of Environmental Health Sciences, Yale School of Public Health
- Tongzhang Zheng
- Department of Environmental Health Sciences, Yale School of Public Health
- Graham G. Giles
- Cancer Epidemiology Centre, Cancer Council Victoria
- Charles Lawrence
- Westat
- Timothy G. Call
- Division of Hematology, Mayo Clinic
- Mark Liebow
- Department of Medicine, Mayo Clinic
- Mads Melbye
- Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut
- Bengt Glimelius
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Larry Mansouri
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Martha Glenn
- Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine
- Karen Curtin
- Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine
- W Ryan Diver
- Epidemiology Research Program, American Cancer Society
- Brian K. Link
- Department of Internal Medicine, Carver College of Medicine, The University of Iowa
- Lucia Conde
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Paige M. Bracci
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Elizabeth A. Holly
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Rebecca D. Jackson
- Division of Endocrinology, Diabetes and Metabolism, Ohio State University
- Lesley F. Tinker
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Yolanda Benavente
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- Paolo Boffetta
- The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Paul Brennan
- International Agency for Research on Cancer
- Marc Maynadie
- Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital
- James McKay
- International Agency for Research on Cancer
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Stephanie Weinstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Zhaoming Wang
- Department of Computational Biology, St Jude Children’s Research Hospital
- Neil E. Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Lindsay M. Morton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Richard K. Severson
- Department of Family Medicine and Public Health Sciences, Wayne State University
- Elio Riboli
- School of Public Health, Imperial College London
- Paolo Vineis
- MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Roel C. H. Vermeulen
- Institute for Risk Assessment Sciences, Utrecht University
- Melissa C. Southey
- Department of Pathology, Genetic Epidemiology Laboratory, University of Melbourne
- Roger L. Milne
- Cancer Epidemiology Centre, Cancer Council Victoria
- Jacqueline Clavel
- Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
- Sabine Topka
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- John J. Spinelli
- Cancer Control Research, BC Cancer Agency
- Peter Kraft
- Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Maria Grazia Ennas
- Department of Biomedical Science, University of Cagliari
- Geoffrey Summerfield
- Department of Haematology, Queen Elizabeth Hospital
- Giovanni M. Ferri
- Interdisciplinary Department of Medicine, University of Bari
- Robert J. Harris
- Department of Molecular and Clinical Cancer Medicine, University of Liverpool
- Lucia Miligi
- Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO)
- Andrew R. Pettitt
- Department of Molecular and Clinical Cancer Medicine, University of Liverpool
- Kari E. North
- Department of Epidemiology, University of North Carolina at Chapel Hill
- David J. Allsup
- Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust
- Joseph F. Fraumeni
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- James R. Bailey
- Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust
- Kenneth Offit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Guy Pratt
- Department of Haematology, Birmingham Heartlands Hospital
- Henrik Hjalgrim
- Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut
- Chris Pepper
- Division of Cancer and Genetics, School of Medicine, Cardiff University
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Chris Fegan
- Cardiff and Vale National Health Service Trust, Heath Park
- Richard Rosenquist
- Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University
- Silvia de Sanjose
- The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Angel Carracedo
- Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER
- Martin J. S. Dyer
- Ernest and Helen Scott Haematological Research Institute, University of Leicester
- Daniel Catovsky
- Division of Molecular Pathology, The Institute of Cancer Research
- Elias Campo
- Institut d’Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic
- James R. Cerhan
- Department of Health Sciences Research, Mayo Clinic
- James M. Allan
- Northern Institute for Cancer Research, Newcastle University
- Nathanial Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Richard Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Susan Slager
- Department of Health Sciences Research, Mayo Clinic
- DOI
- https://doi.org/10.1038/ncomms14175
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Chronic lymphocytic leukaemia has a hereditary component, much of which remains to be identified. Here, the authors perform a genome-wide association study and find new risk loci for the disease, which are associated with genes involved in immune function.
