Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Diva F. Cardoso; Monica  Lopes-Ferreira; Eliana L. Faquim-Mauro; Mahasti S. Macedo; Sandra H. P. Farsky

doi:10.1080/09629350124986

Mediators of Inflammation (Jan 2001)

Role of crotoxin, a phospholipase A2 isolated from Crotalus durissus terrificus snake venom, on inflammatory and immune reactions

Diva F. Cardoso,
Monica Lopes-Ferreira,
Eliana L. Faquim-Mauro,
Mahasti S. Macedo,
Sandra H. P. Farsky

Affiliations

Diva F. Cardoso: Laboratory of Immunopathology, Institute Butantan, Av. Vital Brazil, 1500 São Paulo, São Paulo 05503–900, SP, Brazil
Monica Lopes-Ferreira: Laboratory of Immunopathology, Institute Butantan, Av. Vital Brazil, 1500 São Paulo, São Paulo 05503–900, SP, Brazil
Eliana L. Faquim-Mauro: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
Mahasti S. Macedo: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
Sandra H. P. Farsky: Laboratory of Immunochemistry, Institute Butantan, Av. Vital Brazil, 1500 São Paulo, São Paulo 05503–900, SP, Brazil

DOI: https://doi.org/10.1080/09629350124986
Journal volume & issue: Vol. 10, no. 3
pp. 125 – 133

Abstract

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Background: Crotoxin (CTX) is a potent neurotoxin from Crotalus durissus terrificus snake venom (CdtV) composed of two subunits: one without catalytic activity (crotapotin), and a basic phospolipase A2. Recent data have demonstrated that CdtV or CTX inhibit some immune and inflammatory reactions.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

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