Nature Communications (Jan 2023)
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain
- Shelei Pan,
- Peter H. Yang,
- Dakota DeFreitas,
- Sruthi Ramagiri,
- Peter O. Bayguinov,
- Carl D. Hacker,
- Abraham Z. Snyder,
- Jackson Wilborn,
- Hengbo Huang,
- Gretchen M. Koller,
- Dhvanii K. Raval,
- Grace L. Halupnik,
- Sanja Sviben,
- Samuel Achilefu,
- Rui Tang,
- Gabriel Haller,
- James D. Quirk,
- James A. J. Fitzpatrick,
- Prabagaran Esakky,
- Jennifer M. Strahle
Affiliations
- Shelei Pan
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Peter H. Yang
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Dakota DeFreitas
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Sruthi Ramagiri
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Peter O. Bayguinov
- Washington University Center for Cellular Imaging, Washington University School of Medicine, Washington University in St. Louis
- Carl D. Hacker
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Abraham Z. Snyder
- Department of Radiology, Washington University School of Medicine, Washington University in St. Louis
- Jackson Wilborn
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Hengbo Huang
- Department of Radiology, Washington University School of Medicine, Washington University in St. Louis
- Gretchen M. Koller
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Dhvanii K. Raval
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Grace L. Halupnik
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Sanja Sviben
- Washington University Center for Cellular Imaging, Washington University School of Medicine, Washington University in St. Louis
- Samuel Achilefu
- Department of Biomedical Engineering, UT Southwestern Medical Center
- Rui Tang
- Department of Radiology, Washington University School of Medicine, Washington University in St. Louis
- Gabriel Haller
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- James D. Quirk
- Department of Radiology, Washington University School of Medicine, Washington University in St. Louis
- James A. J. Fitzpatrick
- Washington University Center for Cellular Imaging, Washington University School of Medicine, Washington University in St. Louis
- Prabagaran Esakky
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- Jennifer M. Strahle
- Department of Neurosurgery, Washington University School of Medicine, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-023-36083-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.
