Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway

Meng-Ling Zhang; Qian Yang; Yan-Di Zhu; Ya-Di Zhang; Rui Zhang; Jian Liu; Xiao-Yan Zhao; Qin-Yu Dang; Dong-Xu Huang; Ming-Yuan Zhang; Yu-Chen Wei; Zhuo Hu; Xia-Xia Cai; Li-Fang Gao; Yang Shan; Huan-Ling Yu

doi:10.3390/nu14112332

Nutrients (Jun 2022)

Nobiletin Inhibits Hypoxia-Induced Placental Damage via Modulating P53 Signaling Pathway

Meng-Ling Zhang,
Qian Yang,
Yan-Di Zhu,
Ya-Di Zhang,
Rui Zhang,
Jian Liu,
Xiao-Yan Zhao,
Qin-Yu Dang,
Dong-Xu Huang,
Ming-Yuan Zhang,
Yu-Chen Wei,
Zhuo Hu,
Xia-Xia Cai,
Li-Fang Gao,
Yang Shan,
Huan-Ling Yu

Affiliations

Meng-Ling Zhang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Qian Yang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Yan-Di Zhu: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Ya-Di Zhang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Rui Zhang: School of Medical Humanity, Peking University, Beijing 100191, China
Jian Liu: Hunan Agricultural Product Processing Institute, Hunan Academy of Agricultural Sciences, Hunan Provincial Key Laboratory for Fruits and Vegetables Storage Processing and Quality Safety, Changsha 410082, China
Xiao-Yan Zhao: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Qin-Yu Dang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Dong-Xu Huang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Ming-Yuan Zhang: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Yu-Chen Wei: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Zhuo Hu: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Xia-Xia Cai: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Li-Fang Gao: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
Yang Shan: Hunan Agricultural Product Processing Institute, Hunan Academy of Agricultural Sciences, Hunan Provincial Key Laboratory for Fruits and Vegetables Storage Processing and Quality Safety, Changsha 410082, China
Huan-Ling Yu: School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China

DOI: https://doi.org/10.3390/nu14112332
Journal volume & issue: Vol. 14, no. 11
p. 2332

Abstract

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In this study, we aimed to evaluate the effect of Nobiletin (NOB) on the placenta of Sprague–Dawley (SD) rats that had undergone reduced uterine perfusion pressure (RUPP) surgery and to evaluate the safety of NOB intervention during pregnancy. The results showed that NOB alleviated placental hypoxia, attenuated placental cell apoptosis, and inhibited placental damage in RUPP rats. No side effect of NOB intervention during pregnancy was observed. BeWo cell lines with P53 knockdown were then constructed using lentiviral transfection, and the P53 signaling pathway was found to be essential for NOB to reduce hypoxia-induced apoptosis of the BeWo cell lines. In summary, NOB attenuated hypoxia-induced placental damage by regulating the P53 signaling pathway, and those findings may contribute some insights into the role of NOB in placental development and the prevention of placental-related diseases.

Published in Nutrients

ISSN: 2072-6643 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.mdpi.com/journal/nutrients

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