Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes

Panpan Wu; Ketao Chen; Bowen Li; Yanni Zhang; Hang Wu; Yuhong Chen; Shaohua Ren; Sabir Khan; Lixin Zhang; Buchang Zhang

doi:10.1128/mBio.02298-21

mBio (Oct 2021)

Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes

Panpan Wu,
Ketao Chen,
Bowen Li,
Yanni Zhang,
Hang Wu,
Yuhong Chen,
Shaohua Ren,
Sabir Khan,
Lixin Zhang,
Buchang Zhang

Affiliations

Panpan Wu: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Ketao Chen: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Bowen Li: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Yanni Zhang: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Hang Wu: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Yuhong Chen: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Shaohua Ren: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Sabir Khan: Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China
Lixin Zhang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
Buchang Zhang: ORCiD; Institute of Physical Science and Information Technology, School of Chemistry and Chemical Engineering, School of Life Sciences, Anhui University, Hefei, China

DOI: https://doi.org/10.1128/mBio.02298-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Numerous antibiotics are derived from polyketides, whose biosynthesis is accurately controlled by transcriptional regulators that respond to diverse physiological or environmental signals. It is generally accepted that antibiotics or biosynthetic intermediates serve as effectors to modulate their production in actinomycetes.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal