Nature Communications (Aug 2021)
Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
- Kerui Wu,
- Jiamei Feng,
- Feng Lyu,
- Fei Xing,
- Sambad Sharma,
- Yin Liu,
- Shih-Ying Wu,
- Dan Zhao,
- Abhishek Tyagi,
- Ravindra Pramod Deshpande,
- Xinhong Pei,
- Marco Gabril Ruiz,
- Hiroyuki Takahashi,
- Shunsuke Tsuzuki,
- Takahiro Kimura,
- Yin-yuan Mo,
- Yusuke Shiozawa,
- Ravi Singh,
- Kounosuke Watabe
Affiliations
- Kerui Wu
- Department of Cancer Biology, Wake Forest University School of Medicine
- Jiamei Feng
- Department of Cancer Biology, Wake Forest University School of Medicine
- Feng Lyu
- Department of Cancer Biology, Wake Forest University School of Medicine
- Fei Xing
- Department of Cancer Biology, Wake Forest University School of Medicine
- Sambad Sharma
- Department of Cancer Biology, Wake Forest University School of Medicine
- Yin Liu
- Department of Cancer Biology, Wake Forest University School of Medicine
- Shih-Ying Wu
- Department of Cancer Biology, Wake Forest University School of Medicine
- Dan Zhao
- Department of Cancer Biology, Wake Forest University School of Medicine
- Abhishek Tyagi
- Department of Cancer Biology, Wake Forest University School of Medicine
- Ravindra Pramod Deshpande
- Department of Cancer Biology, Wake Forest University School of Medicine
- Xinhong Pei
- Department of Cancer Biology, Wake Forest University School of Medicine
- Marco Gabril Ruiz
- Department of Cancer Biology, Wake Forest University School of Medicine
- Hiroyuki Takahashi
- Department of Pathology, Jikei University School of Medicine
- Shunsuke Tsuzuki
- Department of Pathology, Jikei University School of Medicine
- Takahiro Kimura
- Department of Pathology, Jikei University School of Medicine
- Yin-yuan Mo
- Cancer Institute, University of Mississippi Medical Center
- Yusuke Shiozawa
- Department of Cancer Biology, Wake Forest University School of Medicine
- Ravi Singh
- Department of Cancer Biology, Wake Forest University School of Medicine
- Kounosuke Watabe
- Department of Cancer Biology, Wake Forest University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25473-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Bone metastasis is a major complication of breast cancer (BC) and ER+ tumors have a higher incidence of bone metastasis than ER− tumors. Here, the authors report that miR‐19a in exosomes and the bone matrix protein, IBSP, are upregulated and secreted by bone tropic ER+ BC cells, where they cooperatively induce osteoclastogenesis and promote bone colonization.
