Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson’s disease patient with RAB39B gene mutation

Huifang Sun; Zhuoya Wang; Qi Zhang; Yutao Liu; Jing Yang; Han Liu; Changhe Shi; Yanlin Wang; Yuming Xu

Stem Cell Research (Aug 2021)

Generation of induced pluripotent stem cell line (ZZUi027-A) derived from skin fibroblasts from a Parkinson’s disease patient with RAB39B gene mutation

Huifang Sun,
Zhuoya Wang,
Qi Zhang,
Yutao Liu,
Jing Yang,
Han Liu,
Changhe Shi,
Yanlin Wang,
Yuming Xu

Affiliations

Huifang Sun: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China; School of Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Zhuoya Wang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Qi Zhang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Yutao Liu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Jing Yang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Han Liu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Changhe Shi: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China
Yanlin Wang: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China; Corresponding authors.
Yuming Xu: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China; Corresponding authors.

Journal volume & issue: Vol. 55
p. 102454

Abstract

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Parkinson's disease is a common neurogenetic degenerative disease that can be caused by a variety of genetic mutations. RAB39B gene mutations have recently been identified as a cause of Parkinson's disease. We collected skin tissue samples from a family with mutations in RAB39B for our clinical study. Additionally, we constructed patient-derived induced pluripotent stem cells (iPSCs) from the patient’s uncle using an unintegrated reprogramming plasmid transfection method to create a reliable cell model for the subsequent study of Parkinson's disease.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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