Evaluation of obstetric outcomes and prognostic significance of graft function in kidney transplant recipient pregnancies

Abstract

Objective To evaluate obstetric and kidney outcomes in pregnancies with kidney transplantation. Methods We retrospectively reviewed 32 singleton pregnancies in kidney transplant recipients. Obstetric outcomes were explored according to the estimated glomerular filtration rates (eGFR) of patients. Results The incidences of fetal growth restriction, preeclampsia were 18.8% and 34.4%, respectively. There was a significant negative correlation between first-trimester eGFR and perinatal mortality (r = −0.546, p = .0.001) and composite adverse obstetric outcome (r = −0.415, p = .0.018). Conclusion The degree of transplanted kidney function impairment at the beginning of pregnancy is the major determinant of pregnancy outcome.

Keywords

• kidney transplant
• pregnancy
• obstetric outcomes
• glomerular filtration rate