Nature Communications (Mar 2020)

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

  • A. Negrete-Hurtado,
  • M. Overhoff,
  • S. Bera,
  • E. De Bruyckere,
  • K. Schätzmüller,
  • M. J. Kye,
  • C. Qin,
  • M. Lammers,
  • V. Kondylis,
  • I. Neundorf,
  • N. L. Kononenko

DOI
https://doi.org/10.1038/s41467-020-15287-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 19

Abstract

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In neurons, the microtubule cytoskeleton provides support and directionality of axons. Here, the authors report that microtubule dynamics in axons may be regulated by the autophagy proteins (ATGs) independently of their known role in autophagy.